HPHY 621: Advanced overview of neural physiology, neural control of human movement, and the biomechanical constraints underlying that control. The objective of this series of courses (HPHY 621, 622, 623) is to provide a scientific foundation for the study of human physiology at the graduate level. This course will consider in depth the mechanisms underlying the neural control of human movement and the biomechanical constraints that are inherent in the human body. The anatomical and neurophysiological characteristics of different sensorimotor structures in the brain will be discussed. In addition, the forces acting at different joints in the body and the resulting kinematic characteristics resulting from those forces will be considered.
HPHY 413: Physiologic basis for skeletal muscle adaptation to increased and decreased use and injury. Emphasizes how structure dictates function relevant to rehabilitation. This course will cover skeletal muscle cell/tissue physiology with a focus on adaptation to increased and decreased use, and response to injury using experimental conditions that demonstrate how structure dictates function. Chapter 1 will cover muscle development and anatomy as the significance of structure throughout the course. Chapter 2 will focus on mechanical and physiological properties of skeletal muscle, including muscle structure-functional relationships and neuromuscular system. Chapter 3 focuses on the way muscles, tendons, and joints interact to produce movement and integrate the information form chapters 1 and 2. Chapter 4 presents various models of increased use and detailing the various cellular responses to experimental conditions resulting in adaptive change to ‘increased use.’ Chapter 5 describes models of decreased use and how muscle cells adapt. Chapter 6 will cover the response to injury and integrate clinical manifestations of increased, decreased use with injury response, i.e., Ch 4-6. Relevant journal articles will be integrated with chapters 4-6 that will emphasize rehabilitation and biomedical application. Prereqs apply. Restricted to HPHY majors.
HPHY 414: Metabolic basis for skeletal muscle adaptation to increased and decreased use, and injury models. Emphasizes inter-organ communication; uses clinical models. This course will cover skeletal muscle cell/tissue metabolism with a focus on adaptation to increased and decreased use, and response to injury using experimental conditions that demonstrate how skeletal muscle serves as the primary amino acid reservoir for whole body homeostasis. The first half of this course will cover basic skeletal muscle biochemistry and metabolism from selected book chapters and primary research articles. We will cover bioenergetics; ATP homeostasis; glycogenolysis and glycolysis; cellular oxidation of Pyruvate and Lactate; lipid metabolism; metabolism of proteins and amino acids. The second half of this course will use primary journal articles covering muscle metabolism as it relates to muscle protein anabolism and catabolism, starvation, immobilization with clinically relevant examples and how functional mobility is affected in young and older populations. Prereqs apply. Restricted to HPHY majors.