The Muscle Biology Laboratory is dedicated to identifying mechanisms that explain age-related changes to skeletal muscle structure and function with a focus on coordination between these two characteristics. We use this knowledge to test novel interventions that improve rehabilitation outcomes in older adults at risk for physical disability.

Cross section of human skeletal muscle before (above) and after (below) disuse. Notice smaller MHC I (red) and MHC IIA (black) fibers with disuse.