Muscle Biology and Human Aging

Mitochondria isolated from skeletal muscle, fixed in Karnovsky’s solution, and imaged using electron microscopy

 

What are the aspects of cellular function that best predict physical function and independence in older adults at risk for disability? How can we improve rehabilitation outcomes for older adults subjected to bed rest or inpatient treatment?

Quantitative and qualitative changes to skeletal muscle play a role in shaping rehabilitation outcomes following a clinical insult. We are dedicated to improving those outcomes by identifying targets for interventions that will improve muscle health during periods of acute and prolonged disuse.